Abstract
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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Bordetella Infections / microbiology*
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Gene Expression Regulation, Bacterial
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Humans
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Signal Transduction*
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Transcription Factors / genetics
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Transcription Factors / physiology
Substances
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Bacterial Proteins
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BvgA protein, Bacteria
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Transcription Factors
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bvgS protein, Bordetella pertussis