Serum lidocaine concentrations after subcutaneous administration in patients undergoing cardiac catheterization in a pediatric institution

S C Cassidy; P R Jones; S Cox; P D Walson; H D Allen

doi:10.1016/s0022-3476(96)70085-9

Serum lidocaine concentrations after subcutaneous administration in patients undergoing cardiac catheterization in a pediatric institution

J Pediatr. 1996 Sep;129(3):464-6. doi: 10.1016/s0022-3476(96)70085-9.

Authors

S C Cassidy¹, P R Jones, S Cox, P D Walson, H D Allen

Affiliation

¹ Department of Pediatrics, Ohio State University, Columbus, USA.

PMID: 8804342
DOI: 10.1016/s0022-3476(96)70085-9

Abstract

Objective: We wished to determine serum lidocaine concentrations after subcutaneous injection during cardiac catheterization.

Method: Serum lidocaine concentrations were measured in 50 patients during catheterization.

Results: Serum concentration was linearly related to dose per kilogram of body weight. Lidocaine concentrations were therapeutic in 38% of patients.

Conclusion: Lidocaine dose must be considered when the drug is used for local anesthesia in children.

MeSH terms

Anesthetics, Local / administration & dosage
Anesthetics, Local / pharmacokinetics*
Cardiac Catheterization*
Child
Child, Preschool
Humans
Injections, Subcutaneous
Lidocaine / administration & dosage
Lidocaine / blood*
Lidocaine / pharmacokinetics

Substances

Anesthetics, Local
Lidocaine