Abstract
(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1-yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
MeSH terms
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Administration, Oral
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Anti-Ulcer Agents / chemistry
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Anti-Ulcer Agents / therapeutic use*
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Disease Models, Animal
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Epirizole / chemistry*
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Epirizole / pharmacology
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Magnetic Resonance Spectroscopy
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Male
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Peptic Ulcer / drug therapy
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Pyrimidines / chemistry*
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Pyrimidines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
Substances
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Anti-Ulcer Agents
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Pyrimidines
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dulcerozine
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Epirizole