Abstract
In this work, the authors have used technics of multivariate analysis to determine the structure-activity relationships of 46 podophyllotoxin derivatives and analogs studied for their antineoplastic and antiviral activities. The obtained results allow to envisage the possible synthesis of more specific molecules by making modifications in the structure of the model molecular archetype.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Multivariate Analysis
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Podophyllotoxin / analogs & derivatives*
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Podophyllotoxin / pharmacology*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Antiviral Agents
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Podophyllotoxin