Abstract
Our understanding of the etiologies of the Alzheimer diseases is advancing rapidly, led by the discovery of relevant genetic mutations for autosomal-dominant forms of the disease and widespread confirmation of the role played by apolipoprotein E, the major susceptibility gene for the common form of Alzheimer's disease. New hypotheses are being generated and old hypotheses are being modified to account for the wealth of new information.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Alzheimer Disease / genetics*
-
Amyloid beta-Protein Precursor / genetics
-
Apolipoproteins E / genetics*
-
Chromosome Mapping
-
Chromosomes, Human
-
Genes, Dominant
-
Genetic Predisposition to Disease
-
Humans
-
Membrane Proteins / genetics
-
Presenilin-1
Substances
-
Amyloid beta-Protein Precursor
-
Apolipoproteins E
-
Membrane Proteins
-
PSEN1 protein, human
-
Presenilin-1