Case-control study comprised 100 pancreatic cancer patients and the same number of hospital controls individually matched with cases by sex, age and place of residence. According to logistic regression analysis following factors were found to be risk factors for pancreatic cancer: smoking 26 or more cigarettes per day (OR = 43.95, 95% CI = 7.69-192.53), consumption of 5 or more glasses of hard drinks per week (OR = 12.84, 95% CI = 2.13-77.29), coffee consumption during a period exceeding 35 years (OR = 2.50, 95% CI = 1.18-5.28), gall bladder disease in personal history (OR = 4.29, 95% CI = 1.08-16.99) and family history positive on peptic ulcer (OR = 11.71, 95% CI = 0.99-137.98). Two factors appeared to be protective for cancer of pancreas: appendectomy (OR = 0.22, 95% CI = 0.07-0.68) and blood type 0, Rh+ (OR = 0.25, 95% CI = 0.09-0.61).