Abstract
We have isolated cholesteryl ester transfer protein (CETP) inhibitors from the extract of Korean Panax ginseng C. A. Meyer roots and identified them as polyacetylene analogs. These compounds inhibit human CETP with IC50 values of around 20-35 mg/ml.
MeSH terms
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Carrier Proteins / antagonists & inhibitors*
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Cholesterol Ester Transfer Proteins
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Glycoproteins*
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Humans
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Panax / chemistry*
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Plant Extracts / chemistry
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Plants, Medicinal*
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Recombinant Proteins / chemistry
Substances
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CETP protein, human
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Carrier Proteins
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Cholesterol Ester Transfer Proteins
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Glycoproteins
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Plant Extracts
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Recombinant Proteins