Abstract
Descriptions on patients with multifocal motor neuropathy with conduction block (MMNCB), including histology, nerve fiber teasing and electron microscopy on nerve biopsy, are rare. We report a 64-year old female patient with progredient weakness of the upper extremities without sensory deficit. Electrophysiology shows conduction blocks up to 80% in several examined motor nerves. A biopsy of the sensory sural nerve reveals features of a mixed axonal and de- and remyelinating neuropathy. Thus sural nerve biopsy contributes here significantly to differential diagnosis and supports an immune mediated pathogenesis of MMNCB.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Amyotrophic Lateral Sclerosis / diagnosis*
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Amyotrophic Lateral Sclerosis / pathology
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Amyotrophic Lateral Sclerosis / physiopathology
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Axons / pathology
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Axons / physiology
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Biopsy
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Diagnosis, Differential
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Female
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Humans
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Middle Aged
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Motor Neuron Disease / diagnosis*
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Motor Neuron Disease / pathology
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Motor Neuron Disease / physiopathology
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Motor Neurons / pathology
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Motor Neurons / physiology
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Myelin Sheath / pathology
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Myelin Sheath / physiology
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Nerve Degeneration / physiology
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Nerve Fibers / pathology
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Nerve Fibers / physiology
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Nerve Regeneration / physiology
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Neurologic Examination
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Sural Nerve / pathology
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Sural Nerve / physiopathology
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Synaptic Transmission / physiology*