Omeprazole-induced acute interstitial nephritis

Ren Fail. 1997 Jan;19(1):171-5. doi: 10.3109/08860229709026272.

Abstract

Omeprazole is a proton pump inhibitor widely used for the treatment of peptic ulcer disease. We report a patient presenting nonoliguric acute renal failure following omeprazole treatment. Both eosinophilia and eosinophiluria were observed, and the patient was diagnosed as having drug-induced acute interstitial nephritis. Renal failure spontaneously resolved when omeprazole was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Anti-Ulcer Agents / adverse effects*
  • Biopsy
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Duodenal Ulcer / complications
  • Duodenal Ulcer / drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Nephritis, Interstitial / blood
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / pathology
  • Omeprazole / adverse effects*

Substances

  • Anti-Ulcer Agents
  • Creatinine
  • Omeprazole