Abstract
Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have also been described. Finally, growing evidence suggests that proteins may contribute directly to the spliceosome's active sites.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Fungal Proteins / metabolism
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Macromolecular Substances
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Protein Binding
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RNA Precursors / metabolism*
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RNA Splicing*
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RNA, Fungal / metabolism
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RNA, Messenger / metabolism
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Ribonucleoproteins / physiology
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Ribonucleoproteins, Small Nuclear / physiology*
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Saccharomyces cerevisiae
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Spliceosomes / physiology*
Substances
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Fungal Proteins
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Macromolecular Substances
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RNA Precursors
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RNA, Fungal
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RNA, Messenger
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Ribonucleoproteins
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Ribonucleoproteins, Small Nuclear