Abstract
Daily oral 6-week administration of epaden in a dose containing 0.3 g eucosopentanoic acid and 0.05 g docosahexaenoic acid caused decrease in collagen-induced platelet aggregation in rabbits in vivo and in the activity of the tissue type plasminogen activator, as well as reduction in the level of antithrombin III cofactor activity. No changes were encountered in ADP-induced aggregation, in the platelet count, in platelet adhesion to collagen, and in activated partial thromboplastin time.
Publication types
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Comparative Study
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antithrombin III / drug effects
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Blood Coagulation / drug effects*
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Docosahexaenoic Acids / pharmacology*
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Drug Combinations
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Eicosapentaenoic Acid / pharmacology*
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Partial Thromboplastin Time
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Platelet Adhesiveness / drug effects
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / pharmacology*
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Platelet Count / drug effects
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Rabbits
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Time Factors
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Tissue Plasminogen Activator / drug effects
Substances
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Drug Combinations
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Maxepa
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Platelet Aggregation Inhibitors
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Docosahexaenoic Acids
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Antithrombin III
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Eicosapentaenoic Acid
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Tissue Plasminogen Activator