Abstract
The aminoglycoside antibiotics are broad-spectrum antibacterial compounds that are used extensively for the treatment of many bacterial infections. In view of the current concerns over the global rise in antibiotic-resistant microorganisms, there has been renewed interest in the mechanisms of resistance to the aminoglycosides, including the superfamily of aminoglycoside-modifying enzymes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetyltransferases / genetics
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Acetyltransferases / metabolism
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Amino Acid Sequence
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Aminoglycosides
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Carbohydrate Sequence
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Drug Resistance, Microbial / genetics
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Molecular Sequence Data
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Molecular Structure
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Mycobacterium
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Nucleotidyltransferases / genetics
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Nucleotidyltransferases / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases / genetics
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Phosphotransferases / metabolism
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Streptomyces / genetics
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Acetyltransferases
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Phosphotransferases
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Phosphotransferases (Alcohol Group Acceptor)
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streptomycin 6-kinase
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Nucleotidyltransferases
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aminoglycoside 6-adenylyltransferase