Gallium scanning in the 'new' tuberculosis

Clin Nucl Med. 1997 Jul;22(7):470-4. doi: 10.1097/00003072-199707000-00005.

Abstract

Purpose: To evaluate the findings and usefulness of Ga-67 scanning in recent cases of tuberculosis (TB).

Materials and methods: The authors reviewed chest x-ray films and Ga-67 citrate scans of 52 patients with culture-confirmed infection caused by Mycobacterium tuberculosis treated after 1988.

Results: Ga-67 scans were positive in every case, delineating upper lobe lung lesions in 6 patients, diffuse involvement or lower lobe disease in 34 patients, and intrathoracic adenopathy in 15 patients. Pulmonary parenchymal lesions were not detected on x-ray films in 3 patients, and nodal lesions were not apparent in 3 patients. In addition, in 6 patients cervical adenopathy was detected by Ga-67 scintigraphy; 4 underwent biopsy with culture confirmation.

Conclusions: Ga-67 scanning is more sensitive than routine chest radiography for detection of both TB parenchymal lung involvement and adenopathy. Ga-67 imaging facilitates the choice of biopsy sites by identifying accessible peripheral nodes. Typical patterns in recent cases of TB differ significantly from the upper lobe predilection of classical TB.

MeSH terms

  • Adult
  • Citrates*
  • Female
  • Gallium Radioisotopes*
  • Gallium*
  • Humans
  • Lung / diagnostic imaging
  • Male
  • Middle Aged
  • Radiography
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Tuberculosis, Pulmonary / diagnostic imaging*

Substances

  • Citrates
  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • Gallium
  • gallium citrate