Abstract
Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.
MeSH terms
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Agammaglobulinaemia Tyrosine Kinase
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Animals
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Antigens, T-Independent / immunology
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B-Lymphocytes / cytology*
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B-Lymphocytes / enzymology
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Cell Differentiation
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Enzyme Activation
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Humans
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Immunologic Deficiency Syndromes / enzymology*
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / immunology
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Mice
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Mice, Mutant Strains
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Phosphorylation
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Protein Processing, Post-Translational
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Protein-Tyrosine Kinases / physiology*
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Signal Transduction / physiology*
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X Chromosome / genetics
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src-Family Kinases / physiology
Substances
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Antigens, T-Independent
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Protein-Tyrosine Kinases
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Agammaglobulinaemia Tyrosine Kinase
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BTK protein, human
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Btk protein, mouse
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src-Family Kinases