Cell-mediated autoimmune diseases of the skin: some hypotheses

Med Hypotheses. 1997 Sep;49(3):241-5. doi: 10.1016/s0306-9877(97)90209-7.

Abstract

The propensity of most autoimmune diseases to manifest themselves in the skin may result from faulty teaching of what is 'self' by epithelial cells in the thymus. Whether T cells learn what is 'self' in the thymus or not until later, peripheral to the thymus, may explain the wide range of severity of autoimmune diseases. Also, I suggest that lichen planus, alopecia areata, vitiligo and psoriasis, as well as sarcoidosis and granuloma annulare are autoimmune in nature.

MeSH terms

  • Alopecia Areata / immunology
  • Autoimmune Diseases / immunology*
  • Granuloma Annulare / immunology
  • Humans
  • Immunity, Cellular
  • Lichen Planus / immunology
  • Models, Immunological*
  • Psoriasis / immunology
  • Sarcoidosis / immunology
  • Skin Diseases / immunology*
  • T-Lymphocytes / immunology*
  • Thymus Gland / immunology
  • Vitiligo / immunology