Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

Mol Cell Endocrinol. 1997 Aug 8;131(2):167-72. doi: 10.1016/s0303-7207(97)00103-2.

Abstract

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Escherichia coli
  • Female
  • Gene Expression Regulation
  • Lipopolysaccharides / pharmacology*
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Skeletal / metabolism*
  • Myocardium / metabolism*
  • RNA, Messenger / metabolism*
  • Receptors, Corticotropin-Releasing Hormone / genetics*

Substances

  • Lipopolysaccharides
  • RNA, Messenger
  • Receptors, Corticotropin-Releasing Hormone