Abstract
Twenty-three patients from Rio de Janeiro, Brazil-an area of Leishmania (Viannia) braziliensis transmission-were randomly assigned to receive either a high dose (20 mg/kg/day) of antimony or a lower one (5 mg/kg/day) in a 30 days series. The two treatment regimens showed similar responses. In 10 out of 12 patients receiving a dose of 5 mg/kg/day and 9 out of 11 patients with a dosage of 20 mg/kg/day a complete epithelization was noted by the end of treatment. In addition patients were followed for up to 7 years. No reactivation or development of mucosal lesions were observed in both groups during the extensive follow-up. We think that a low dosage of antimony could be equally effective than a higher one, at least in the presence of the clinical picture usually seen in Rio de Janeiro.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antimony / administration & dosage
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Antimony / adverse effects
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Antimony / therapeutic use*
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Antiprotozoal Agents / administration & dosage
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Antiprotozoal Agents / adverse effects
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Antiprotozoal Agents / therapeutic use*
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Dose-Response Relationship, Drug
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Double-Blind Method
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Drug Administration Schedule
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Follow-Up Studies
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Humans
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Leishmaniasis, Cutaneous / drug therapy*
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Meglumine / administration & dosage
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Meglumine / adverse effects
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Meglumine / therapeutic use*
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Meglumine Antimoniate
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / adverse effects
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Organometallic Compounds / therapeutic use*
Substances
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Antiprotozoal Agents
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Organometallic Compounds
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Meglumine
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Meglumine Antimoniate
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Antimony