Abstract
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The tumor site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fifty-five percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Apoptosis
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / diagnosis*
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Carcinoma, Squamous Cell / mortality
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Cell Division
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DNA Mutational Analysis
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DNA, Neoplasm / analysis
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Female
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Follow-Up Studies
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Head and Neck Neoplasms / chemistry
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Head and Neck Neoplasms / diagnosis*
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Head and Neck Neoplasms / mortality
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Humans
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Immunohistochemistry
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Ki-67 Antigen / analysis*
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Ki-67 Antigen / genetics
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Male
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Middle Aged
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Polymorphism, Single-Stranded Conformational
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Predictive Value of Tests
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Prognosis
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Proliferating Cell Nuclear Antigen / analysis*
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Proliferating Cell Nuclear Antigen / genetics
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Proto-Oncogene Proteins c-bcl-2 / analysis*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Survival Analysis
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Tumor Suppressor Protein p53 / analysis*
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Tumor Suppressor Protein p53 / genetics
Substances
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DNA, Neoplasm
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Ki-67 Antigen
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Proliferating Cell Nuclear Antigen
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53