CD26 as a positive regulator of HIV envelope-glycoprotein induced apoptosis in CD4+ T cells

E Jacotot; C Callebaut; J Blanco; Y Rivière; B Krust; A G Hovanessian

doi:10.1007/978-1-4757-9613-1_27

CD26 as a positive regulator of HIV envelope-glycoprotein induced apoptosis in CD4+ T cells

Adv Exp Med Biol. 1997:421:207-16. doi: 10.1007/978-1-4757-9613-1_27.

Authors

E Jacotot¹, C Callebaut, J Blanco, Y Rivière, B Krust, A G Hovanessian

Affiliation

¹ Unité de Virologie et Immunologie Cellulaire, UA CNRS 1157 Institut Pasteur, Paris, France.

PMID: 9330699
DOI: 10.1007/978-1-4757-9613-1_27

Abstract

The membrane-expressed HIV-1 envelope glycoprotein complex, gp120/gp41, has been shown to be responsible for the initiation of cell killing by apoptosis in CD4+ T cells. By using two experimental approaches we demonstrate that CD26, independent of its DPP IV activity, appears to be implicated in this function of the gp120/gp41 complex to initiate apoptosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis*
CD4-Positive T-Lymphocytes / pathology
CD4-Positive T-Lymphocytes / physiology*
CD4-Positive T-Lymphocytes / virology
Dipeptidyl Peptidase 4 / physiology*
HIV Envelope Protein gp120 / physiology*
HIV Infections
HIV-1*
Humans

Substances

HIV Envelope Protein gp120
Dipeptidyl Peptidase 4