Abstract
The components responsible for protein translocation across the endoplasmic reticulum membrane have been identified and their functions have been clarified in vitro. The structural features of the signal peptide specify the factors and pathways of membrane translocation. Various chaperones and folding enzymes are involved in the folding and quality control of secretory proteins in the lumen.
MeSH terms
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Animals
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Biotechnology / methods
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Cloning, Molecular / methods
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Endoplasmic Reticulum / metabolism*
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Enzymes / biosynthesis*
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Enzymes / chemistry
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Gene Transfer Techniques
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Humans
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Molecular Chaperones / physiology
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Protein Folding
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Protein Processing, Post-Translational
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Protein Sorting Signals
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Recombinant Proteins / biosynthesis*
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Recombinant Proteins / chemistry
Substances
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Enzymes
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Molecular Chaperones
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Protein Sorting Signals
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Recombinant Proteins