Abstract
T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling.
MeSH terms
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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CD4 Antigens / metabolism
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Histocompatibility Antigens Class II / metabolism
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Humans
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Receptors, Antigen, T-Cell / metabolism*
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Signal Transduction*
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
Substances
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CD4 Antigens
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Histocompatibility Antigens Class II
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Receptors, Antigen, T-Cell