Abstract
We determined the distribution of DR4 subtypes in 309 DQB1*0302-positive haplotypes found in insulin-dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA-B39 was more frequent in DRB1*0404-DQB1*0302-positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA-DRB1 in the susceptibility to IDDM.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adolescent
-
Alleles*
-
Child
-
Child, Preschool
-
Diabetes Mellitus, Type 1 / epidemiology
-
Diabetes Mellitus, Type 1 / genetics*
-
Diabetes Mellitus, Type 1 / immunology
-
Disease Susceptibility
-
Finland / epidemiology
-
Gene Frequency
-
Genetic Linkage
-
HLA-B Antigens / analysis
-
HLA-B Antigens / genetics*
-
HLA-DQ Antigens / genetics
-
HLA-DQ beta-Chains
-
HLA-DR Antigens / analysis
-
HLA-DR Antigens / genetics*
-
HLA-DR4 Antigen / analysis
-
HLA-DR4 Antigen / genetics*
-
HLA-DRB1 Chains
-
Haplotypes / genetics*
-
Humans
-
Risk Factors
Substances
-
HLA-B Antigens
-
HLA-DQ Antigens
-
HLA-DQ beta-Chains
-
HLA-DQB1 antigen
-
HLA-DR Antigens
-
HLA-DR4 Antigen
-
HLA-DRB1 Chains
-
HLA-DRB1*04:01 antigen