Abstract
Apolipoprotein E (Apo E) epsilon 4 allele is a risk factor for early and late onset Alzheimer's disease. This prompted us to examine other neurophyschiatric phenotypes. Epsilon 4 allele was significantly enriched in Lewy body dementia (n = 39) but not in Parkinson's disease (n = 50) or Schizophrenia (n = 175) compared to aged non-demented controls (n = 47) and the Scottish population (n = 400). We conclude that Lewy body disease should be regarded as a variant of Alzheimer's but not Parkinson's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alleles
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Alzheimer Disease / genetics*
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Alzheimer Disease / metabolism
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Apolipoproteins E / genetics*
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Apolipoproteins E / metabolism
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Dementia / genetics
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Dementia / pathology
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Female
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Humans
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Lewy Bodies / genetics*
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Lewy Bodies / metabolism
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Male
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Middle Aged
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Presenilin-1
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Risk Factors
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Schizophrenia / genetics
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Schizophrenia / metabolism
Substances
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Apolipoproteins E
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Membrane Proteins
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PSEN1 protein, human
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Presenilin-1