In the past decade, an explosion of interest in pediatric pain has resulted in the proliferation of research studies. This review examines 41 studies that focus on pharmacologic interventions in children during the last decade. Criteria for inclusion in this paper were studies that (1) tested a pharmacological intervention prospectively, (2) were conducted with children only, (3) had a sample size over 30, (4) randomly assigned participants to two or more groups, and (5) provided sufficient methodological and statistical detail for critique. Studies focused on postoperative and procedural pain, were conducted most frequently with pre-school-aged children or older, and demonstrated the efficacy of pharmacologic interventions.