The bark of the yohimbine tree has long been appreciated as an aphrodisiac. Recent studies have shown that yohimbine is effective in the symptomatic treatment of erectile dysfunction. It is superior to placebo and has fewer side effects compared with the invasive treatment of erectile dysfunction. The evidence for effectiveness seems less compelling for other oral drugs used in this condition. It can be concluded that yohimbine is an attractive option in the symptomatic treatment of erectile dysfunction.