Abstract
Cyclin C was originally identified in a genetic screen for metazoan cDNAs that complement a triple knock-out of the CLN genes, involved in G1/S progression in S. cerevisiae. Unlike cyclin Ds and cyclin E, also identified in this screen, cyclin C has not been found to have a cell-cycle role in metazoa. Identified as the catalytic partner of cyclin C, Cdk8 is a novel protein-kinase of the Cdk family structurally related to the yeast Srb10 kinase. Cyclin C, Cdk8 and RNA polymerase II are found in a large multi-protein complex that shows structural as well as functional homologies with the yeast polymerase II holoenzyme. These observations and the sequence similarity to the kinase/cyclin pair Srb10/Srb11 in S. cerevisiae, suggest that cyclin C and Cdk8 control RNA polymerase II function.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigen-Antibody Complex
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Cyclin C
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Cyclin-Dependent Kinase 8
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Cyclin-Dependent Kinases*
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Cyclins / chemistry
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Cyclins / genetics
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Cyclins / physiology*
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Genes, Fungal
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Humans
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Macromolecular Substances
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Models, Biological
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Molecular Sequence Data
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Multienzyme Complexes / chemistry
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Multienzyme Complexes / physiology
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / physiology*
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RNA Polymerase II / chemistry
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RNA Polymerase II / physiology
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae Proteins
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Sequence Homology, Amino Acid
Substances
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Antigen-Antibody Complex
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CCNC protein, human
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Cyclin C
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Cyclins
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Macromolecular Substances
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Multienzyme Complexes
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Saccharomyces cerevisiae Proteins
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Protein Serine-Threonine Kinases
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CDK8 protein, human
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Cyclin-Dependent Kinase 8
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Cyclin-Dependent Kinases
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SSN3 protein, S cerevisiae
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RNA Polymerase II