Costimulatory molecules (CD80 and CD86) on Reed-Sternberg cells are associated with the proliferation of background T cells in Hodgkin's disease

Pathol Int. 1998 Jan;48(1):10-4. doi: 10.1111/j.1440-1827.1998.tb03821.x.

Abstract

To elucidate the relationship between Reed-Sternberg (R-S) cells and background T cells, the expression of CD80 and CD86 of R-S cells in Hodgkin's disease (HD), and the ligand CD28 expression and the MIB-1 index of background T cells were immunohistochemically investigated. CD80 and CD86 were found to be expressed on R-S cells in almost all cases of HD. CD28 was expressed with strong intensity on many background T cells around R-S cells. The MIB-1 index of background T cells was 30.3% (range, 15.5-38.9%) and was much higher than 10.9% (range, 9.8-11.7%) in B cell lymphomas. These results suggest that the interaction between CD80 and CD86 on R-S cells, and CD28 on background T cells may induce T cell proliferation and be associated with tumor mass of HD.

MeSH terms

  • Antigens, CD / metabolism*
  • Antigens, Nuclear
  • B7-1 Antigen / metabolism*
  • B7-2 Antigen
  • CD28 Antigens / metabolism
  • CD3 Complex / metabolism
  • DNA-Binding Proteins / metabolism
  • Hodgkin Disease / immunology*
  • Hodgkin Disease / pathology
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen
  • Leukocyte Common Antigens / metabolism
  • Lymphoma, B-Cell / metabolism
  • Membrane Glycoproteins / metabolism*
  • Microscopy, Immunoelectron
  • Nuclear Proteins / metabolism
  • Reed-Sternberg Cells / immunology*
  • T-Lymphocytes / metabolism*
  • T-Lymphocytes / pathology

Substances

  • Antigens, CD
  • Antigens, Nuclear
  • B7-1 Antigen
  • B7-2 Antigen
  • CD28 Antigens
  • CD3 Complex
  • CD86 protein, human
  • DNA-Binding Proteins
  • Ki-67 Antigen
  • Membrane Glycoproteins
  • Nuclear Proteins
  • Leukocyte Common Antigens