Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol

Prog Neuropsychopharmacol Biol Psychiatry. 1998 Apr;22(3):523-8. doi: 10.1016/s0278-5846(98)00022-0.

Abstract

1. Two hundred male albino Sprague-Dawley rats were studied for the lithium and/or inositol effect on 5-HTP induced prolactin release. 2. Lithium demonstrated a clear augmentation of 5-HTP induced prolactin levels, however no effect of inositol was demonstrated on lithium augmentation of 5-HTP induced prolactin release.

MeSH terms

  • 5-Hydroxytryptophan / pharmacology*
  • Animals
  • Antipsychotic Agents / pharmacology*
  • Drug Synergism
  • Inositol / pharmacology*
  • Lithium / pharmacology*
  • Male
  • Prolactin / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Antipsychotic Agents
  • Inositol
  • Prolactin
  • Lithium
  • 5-Hydroxytryptophan