I have added 16 cases to the preciously reported 4 cases where ophthalmologic complications occurred in connection with oral contraceptives. In some cases, occlusion of the central retinal artery, prethrombosis of the central retinal vein, prolonged narrowing of the retinal arteries, perivasculitis, hemorrhage in the macular region, and inflammations of the anterior segment of the eye, resistance to therapy developed, and in some cases, lesions of the optic nerve causing visual loss of different degree and papillitis occurred. In the background of the different clinical entities, common pathologic origin might be supposed,--the disturbance of the chorooretinal circulation. In patients taking the pill for the longest time interval, delicate lenticular opacities developed.