Autoradiographic localisation of substance P (NK1) receptors in human primary visual cortex

Brain Res. 1998 Jun 1;794(2):309-12. doi: 10.1016/s0006-8993(98)00270-4.

Abstract

This study utilised autoradiography to examine [125I]-Bolton Hunter substance P (BHSP) binding in postmortem human visual cortex. In the primary visual area, layers I-III, IVC and VI exhibited low levels of BHSP binding, while high levels were observed in layers IVB and V. Because cells in layers IVB and V are known to be involved in processing direction-specific stimuli, it is possible that SP plays a role in modulating this visual process.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoradiography
  • Humans
  • Male
  • Middle Aged
  • Radioligand Assay
  • Receptors, Neurokinin-1 / analysis*
  • Visual Cortex / chemistry*

Substances

  • Receptors, Neurokinin-1