HMG-CoA reductase inhibitors pravastatin and simvastatin inhibit human B-lymphocyte activation

Transplant Proc. 1998 Jun;30(4):992-5. doi: 10.1016/s0041-1345(98)00123-7.

Authors

S M Rudich¹, P K Mongini, R V Perez, S Katznelson

Affiliation

¹ Department of Surgery, UC Davis Medical Center, Sacramento 95817, USA.

PMID: 9636401
DOI: 10.1016/s0041-1345(98)00123-7

No abstract available

MeSH terms

Antibodies, Monoclonal / pharmacology
B-Lymphocytes / drug effects
B-Lymphocytes / immunology*
CD40 Antigens / immunology
CD40 Antigens / physiology
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Interleukin-4 / pharmacology
Kinetics
Lymphocyte Activation / drug effects*
Mitogens
Palatine Tonsil
Pravastatin / pharmacology*
Recombinant Proteins / pharmacology
Simvastatin / pharmacology*

Substances

Antibodies, Monoclonal
CD40 Antigens
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mitogens
Recombinant Proteins
Interleukin-4
Simvastatin
Pravastatin