Abstract
Background:
Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease.
Method:
Case Studies.
Result:
Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy.
Conclusion:
Pathological laughter can be a side effect of intravenous sodium valproate.
MeSH terms
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Adolescent
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Adult
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Anticonvulsants / administration & dosage
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Anticonvulsants / adverse effects*
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Humans
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Injections, Intravenous
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Laughter / psychology*
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Male
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Mental Disorders / chemically induced*
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Mental Disorders / psychology*
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Seizures / complications
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Seizures / drug therapy
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Seizures / psychology
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Valproic Acid / administration & dosage
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Valproic Acid / adverse effects*
Substances
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Anticonvulsants
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Valproic Acid