Abstract
It has recently been shown that mammals contain a gene encoding a protein that is related to stanniocalcin (STC), a hormone previously considered to be present only in bony fish where it plays a major role in Ca2+ homeostasis. Here we report the identification in the mouse and human of a cDNA, STC-2, that shows significant similarity to the first mammalian STC (which we now rename STC-1). Northern analysis revealed that mammalian STC-2, like STC-1, is expressed in a wide variety of tissues. In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternative Splicing
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Cloning, Molecular
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DNA, Complementary / genetics
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DNA, Complementary / isolation & purification
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Databases, Factual
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Expressed Sequence Tags
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Glycoproteins / chemistry
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Glycoproteins / genetics*
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Hormones / chemistry
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Hormones / genetics*
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Humans
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Intercellular Signaling Peptides and Proteins
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Intracellular Signaling Peptides and Proteins
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Mice
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Molecular Sequence Data
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Open Reading Frames
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Organ Specificity
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Phylogeny
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Untranslated Regions
Substances
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DNA, Complementary
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Glycoproteins
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Hormones
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Intercellular Signaling Peptides and Proteins
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Intracellular Signaling Peptides and Proteins
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STC2 protein, human
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Stc2 protein, mouse
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Untranslated Regions
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teleocalcin
Associated data
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GENBANK/AF055460
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GENBANK/AF056244