Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain

Brain Res Mol Brain Res. 1998 Aug 15;59(1):90-2. doi: 10.1016/s0169-328x(98)00146-6.

Abstract

We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Brain / metabolism*
  • Genomic Imprinting*
  • Humans
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / genetics*

Substances

  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin