Abstract
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Movement
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Congenital Abnormalities / genetics
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Embryonic and Fetal Development / genetics
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Embryonic and Fetal Development / physiology*
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Epithelial Cells / cytology
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Epithelial Cells / drug effects
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Heparan Sulfate Proteoglycans / metabolism
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Hepatocyte Growth Factor / chemistry
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Hepatocyte Growth Factor / physiology*
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Humans
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Liver / embryology
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Mesoderm / metabolism
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Mice
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Mice, Knockout
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Models, Molecular
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Morphogenesis / physiology
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Muscles / embryology
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Nervous System / embryology
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Neurons / physiology
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PAX3 Transcription Factor
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Paired Box Transcription Factors
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Protein Conformation
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Proto-Oncogene Proteins c-met / genetics
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Proto-Oncogene Proteins c-met / physiology*
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Proto-Oncogenes
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Signal Transduction
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Transcription Factors*
Substances
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DNA-Binding Proteins
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Heparan Sulfate Proteoglycans
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PAX3 Transcription Factor
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PAX3 protein, human
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Paired Box Transcription Factors
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Transcription Factors
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Pax3 protein, mouse
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Hepatocyte Growth Factor
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Proto-Oncogene Proteins c-met