Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

Trends Cell Biol. 1998 Oct;8(10):404-10. doi: 10.1016/s0962-8924(98)01359-2.

Abstract

A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Congenital Abnormalities / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Embryonic and Fetal Development / genetics
  • Embryonic and Fetal Development / physiology*
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects
  • Heparan Sulfate Proteoglycans / metabolism
  • Hepatocyte Growth Factor / chemistry
  • Hepatocyte Growth Factor / physiology*
  • Humans
  • Liver / embryology
  • Mesoderm / metabolism
  • Mice
  • Mice, Knockout
  • Models, Molecular
  • Morphogenesis / physiology
  • Muscles / embryology
  • Nervous System / embryology
  • Neurons / physiology
  • PAX3 Transcription Factor
  • Paired Box Transcription Factors
  • Protein Conformation
  • Proto-Oncogene Proteins c-met / genetics
  • Proto-Oncogene Proteins c-met / physiology*
  • Proto-Oncogenes
  • Signal Transduction
  • Transcription Factors*

Substances

  • DNA-Binding Proteins
  • Heparan Sulfate Proteoglycans
  • PAX3 Transcription Factor
  • PAX3 protein, human
  • Paired Box Transcription Factors
  • Transcription Factors
  • Pax3 protein, mouse
  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met