Abstract
Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed alpha-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of alpha-catenin and the ensuing acquisition of invasiveness in all four cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Colonic Neoplasms / genetics*
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Colonic Neoplasms / pathology
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Cytoskeletal Proteins / analysis
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Cytoskeletal Proteins / genetics*
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DNA Fingerprinting*
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DNA, Neoplasm / genetics*
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Genetic Markers
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Humans
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Karyotyping
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Neoplasm Proteins / analysis
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Neoplasm Proteins / genetics*
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Trans-Activators*
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Tumor Cells, Cultured* / pathology
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beta Catenin
Substances
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CTNNB1 protein, human
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Cytoskeletal Proteins
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DNA, Neoplasm
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Genetic Markers
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Neoplasm Proteins
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Trans-Activators
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beta Catenin