New approaches to structure determination by NMR spectroscopy

V Dötsch; G Wagner

doi:10.1016/s0959-440x(98)80154-1

New approaches to structure determination by NMR spectroscopy

Curr Opin Struct Biol. 1998 Oct;8(5):619-23. doi: 10.1016/s0959-440x(98)80154-1.

Authors

V Dötsch¹, G Wagner

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. volker@picasso.ucsf.edu

PMID: 9818267
DOI: 10.1016/s0959-440x(98)80154-1

Abstract

New strategies have recently been developed for studying biological macromolecules of large size (beyond 100 kDa) in order to both improve the quality of the structures and make structure determination more efficient. This has been achieved by utilizing cross-correlation effects and novel labeling strategies, and developing novel NMR spectroscopy experiments.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Isotope Labeling / methods*
Magnetic Resonance Spectroscopy / methods*
Proteins / chemistry*

Substances

Proteins