Serum leptin in obese patients with Laron syndrome before and during IGF-I treatment

J Pediatr Endocrinol Metab. 1998 Sep-Oct;11(5):653-6. doi: 10.1515/JPEM.1998.11.5.653.

Abstract

Fifteen patients with primary GH resistance (Laron syndrome, LS) were studied before and during 6 months of daily replacement treatment with IGF-I. The main findings were that patients with LS and normal or high serum GH binding protein (GHBP) were less obese than those with a negative GHBP, and that serum leptin levels varied with body mass as in other types of obesity.

MeSH terms

  • Adult
  • Body Composition
  • Carrier Proteins / blood
  • Child
  • Child, Preschool
  • Drug Resistance
  • Female
  • Human Growth Hormone
  • Humans
  • Infant
  • Insulin / blood
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor I / deficiency
  • Insulin-Like Growth Factor I / therapeutic use*
  • Leptin
  • Male
  • Mutation*
  • Obesity / blood*
  • Obesity / drug therapy
  • Obesity / genetics*
  • Proteins / analysis*
  • Receptors, Leptin
  • Receptors, Somatotropin / genetics*

Substances

  • Carrier Proteins
  • Insulin
  • LEPR protein, human
  • Leptin
  • Proteins
  • Receptors, Leptin
  • Receptors, Somatotropin
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • somatotropin-binding protein