Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

J Neuroimmunol. 1998 Nov 2;91(1-2):135-46. doi: 10.1016/s0165-5728(98)00166-0.

Abstract

The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a proteolipid protein (PLP) specific line. Furthermore, Cop 1 Ts cells ameliorated EAE induced by two unrelated encephalitogenic epitopes of PLP: p139-151 and p178-191, that produced different forms of disease. This bystander suppression demonstrated by the Cop 1 Ts cells may explain the therapeutic effect of Cop 1 in EAE and MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Clone Cells
  • Cross Reactions
  • Cytokines / immunology
  • Encephalomyelitis, Autoimmune, Experimental / chemically induced
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Epitopes / immunology
  • Female
  • Glatiramer Acetate
  • Immunosuppressive Agents / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Multiple Sclerosis / immunology
  • Myelin Basic Protein / immunology
  • Myelin Proteolipid Protein / immunology
  • Myelin Proteolipid Protein / pharmacology
  • Peptide Fragments / immunology
  • Peptide Fragments / pharmacology
  • Peptides / immunology*
  • Th2 Cells / chemistry
  • Th2 Cells / cytology
  • Th2 Cells / immunology*

Substances

  • Cytokines
  • Epitopes
  • Immunosuppressive Agents
  • Myelin Basic Protein
  • Myelin Proteolipid Protein
  • Peptide Fragments
  • Peptides
  • myelin proteolipid protein (139-151)
  • myelin proteolipid protein (178-191)
  • Glatiramer Acetate