Determination of drug-metabolizing enzyme activity in vivo: pharmacokinetic and statistical issues

Xenobiotica. 1998 Dec;28(12):1255-73. doi: 10.1080/004982598238895.

Authors

G T Tucker¹, A Rostami-Hodjegan, P R Jackson

Affiliation

¹ University of Sheffield, Division of Clinical Sciences, Royal Hallamshire Hospital, UK.

PMID: 9890160
DOI: 10.1080/004982598238895

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Area Under Curve
Caffeine / metabolism
Caffeine / pharmacokinetics
Cytochrome P-450 Enzyme System / genetics*
Cytochrome P-450 Enzyme System / metabolism*
Genetic Variation
Genetics, Population
Humans
Inactivation, Metabolic*
Models, Biological
Models, Statistical
Pharmacokinetics*
Polymorphism, Genetic
Reproducibility of Results

Substances

Caffeine
Cytochrome P-450 Enzyme System