Identification of the autoantigen of celiac disease

Ann N Y Acad Sci. 1998 Nov 17:859:121-6. doi: 10.1111/j.1749-6632.1998.tb11116.x.

Abstract

Tissue transglutaminase is demonstrated to be the unknown endomysial autoantigen by means of immunoprecipitations from a fibrosarcoma cell culture. A novel hypothesis for the pathogenesis of celiac disease is formulated: The mainly intracellular tissue transglutaminase is released from cells during wound healing where it aids in stabilizing the wound area by cross-linking a small set of extracellular matrix components.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / blood*
  • Autoantigens / immunology*
  • Celiac Disease / immunology*
  • Celiac Disease / physiopathology
  • Fibrosarcoma / immunology
  • GTP Phosphohydrolases / immunology*
  • GTP-Binding Proteins*
  • Humans
  • Immunoglobulin A / blood
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases / immunology*
  • Tumor Cells, Cultured
  • Wound Healing

Substances

  • Autoantibodies
  • Autoantigens
  • Immunoglobulin A
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases
  • GTP Phosphohydrolases
  • GTP-Binding Proteins