Abstract
Tissue transglutaminase is demonstrated to be the unknown endomysial autoantigen by means of immunoprecipitations from a fibrosarcoma cell culture. A novel hypothesis for the pathogenesis of celiac disease is formulated: The mainly intracellular tissue transglutaminase is released from cells during wound healing where it aids in stabilizing the wound area by cross-linking a small set of extracellular matrix components.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Autoantibodies / blood*
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Autoantigens / immunology*
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Celiac Disease / immunology*
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Celiac Disease / physiopathology
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Fibrosarcoma / immunology
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GTP Phosphohydrolases / immunology*
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GTP-Binding Proteins*
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Humans
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Immunoglobulin A / blood
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases / immunology*
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Tumor Cells, Cultured
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Wound Healing
Substances
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Autoantibodies
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Autoantigens
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Immunoglobulin A
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases
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GTP Phosphohydrolases
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GTP-Binding Proteins