Neonatal reversible focal cerebral ischemia: a new model

Neurosci Res. 1998 Dec;32(4):349-53. doi: 10.1016/s0168-0102(98)00096-0.

Abstract

While numerous animal models exist for studying neonatal brain injury after cerebral ischemia-hypoxia, an adequate model for assessing reversible focal ischemia in the neonatal rat has not been reported. This paper describes in detail a new surgical procedure for creating a non-hemorrhagic, reperfused focal ischemic lesion in the neonatal, 7-day-old rat pup.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain Ischemia* / etiology
  • Cerebral Arteries*
  • Disease Models, Animal*
  • Female
  • Ligation / methods
  • Rats
  • Rats, Sprague-Dawley
  • Suture Techniques