Pure red cell aplasia associated to clonal CD8+ T-cell large granular lymphocytosis: dependence on cyclosporin A therapy

Acta Haematol. 1998;100(4):207-10. doi: 10.1159/000040906.

Abstract

This case report details a single patient with pure red cell aplasia (PRCA) associated with clonal CD3+, TCRalphabeta+, TCR-Vbeta8+, CD8+, CD57+ large granular lymphocytosis whose anaemia did not respond to conventional immunosuppressive therapy but did respond to cyclosporin A (CsA). The patient has become dependent on CsA for 7 years in order to control anaemia due to associated PRCA.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • CD8-Positive T-Lymphocytes / pathology*
  • Cell Size
  • Clone Cells
  • Cyclosporine / therapeutic use
  • Cytoplasmic Granules
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lymphocytosis / complications*
  • Lymphocytosis / pathology*
  • Male
  • Middle Aged
  • Red-Cell Aplasia, Pure / complications*
  • Red-Cell Aplasia, Pure / drug therapy
  • Substance-Related Disorders / blood

Substances

  • Immunosuppressive Agents
  • Cyclosporine