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2020 2
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Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium.
Rathjen T, Kunkemoeller B, Cederquist CT, Wang X, Lockhart SM, Patti JC, Willenbrock H, Olsen GS, Povlsen GK, Beck HC, Rasmussen LM, Li Q, Park K, King GL, Rask-Madsen C. Rathjen T, et al. Among authors: lockhart sm. Arterioscler Thromb Vasc Biol. 2022 Jul;42(7):e217-e227. doi: 10.1161/ATVBAHA.122.317476. Epub 2022 Jun 2. Arterioscler Thromb Vasc Biol. 2022. PMID: 35652755 Free PMC article.
The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes.
Lockhart SM, Griffiths H, Petrisor B, Usman A, Calvo-Latorre J, Heales L, Bansiya V, Mahroof R, Conway Morris A. Lockhart SM, et al. Endocrinol Diabetes Metab. 2021 Feb 11;4(3):e00228. doi: 10.1002/edm2.228. eCollection 2021 Jul. Endocrinol Diabetes Metab. 2021. PMID: 34268452 Free PMC article.
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.
Gill D, Arvanitis M, Carter P, Hernández Cordero AI, Jo B, Karhunen V, Larsson SC, Li X, Lockhart SM, Mason A, Pashos E, Saha A, Tan VY, Zuber V, Bossé Y, Fahle S, Hao K, Jiang T, Joubert P, Lunt AC, Ouwehand WH, Roberts DJ, Timens W, van den Berge M, Watkins NA, Battle A, Butterworth AS, Danesh J, Di Angelantonio E, Engelhardt BE, Peters JE, Sin DD, Burgess S. Gill D, et al. Among authors: lockhart sm. R Soc Open Sci. 2020 Nov 18;7(11):200958. doi: 10.1098/rsos.200958. eCollection 2020 Nov. R Soc Open Sci. 2020. PMID: 33391794 Free PMC article.