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Pyridone derivatives as potent and selective VLA-4 integrin antagonists.
Witherington J, Bordas V, Gaiba A, Green PM, Naylor A, Parr N, Smith DG, Takle AK, Ward RW. Witherington J, et al. Among authors: naylor a. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2256-9. doi: 10.1016/j.bmcl.2006.01.025. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455247
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Takle AK, Brown MJ, Davies S, Dean DK, Francis G, Gaiba A, Hird AW, King FD, Lovell PJ, Naylor A, Reith AD, Steadman JG, Wilson DM. Takle AK, et al. Among authors: naylor a. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. doi: 10.1016/j.bmcl.2005.09.072. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16260133
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.
Witherington J, Blaney EL, Bordas V, Elliott RL, Gaiba A, Garton N, Green PM, Naylor A, Smith DG, Spalding DJ, Takle AK, Ward RW. Witherington J, et al. Among authors: naylor a. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5538-41. doi: 10.1016/j.bmcl.2006.08.044. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931004
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
Takle AK, Bamford MJ, Davies S, Davis RP, Dean DK, Gaiba A, Irving EA, King FD, Naylor A, Parr CA, Ray AM, Reith AD, Smith BB, Staton PC, Steadman JG, Stean TO, Wilson DM. Takle AK, et al. Among authors: naylor a. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6. doi: 10.1016/j.bmcl.2008.06.070. Epub 2008 Jun 24. Bioorg Med Chem Lett. 2008. PMID: 18621524
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Bailey N, Bamford MJ, Brissy D, Brookfield J, Demont E, Elliott R, Garton N, Farre-Gutierrez I, Hayhow T, Hutley G, Naylor A, Panchal TA, Seow HX, Spalding D, Takle AK. Bailey N, et al. Among authors: naylor a. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. doi: 10.1016/j.bmcl.2009.04.127. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19467868
Novel C-2 substituted carbapenem derivatives. Part IV. Synthesis and biological activity of five membered heteroaromatic derivatives.
Branch CL, Burton G, Clarke GJ, Coulton S, Douglas JD, Eglington AJ, Guest AW, Hinks JD, Hird NW, Holland RK, Hunt E, Knott SJ, Moss SF, Naylor A, Pearson MJ, Takle AK. Branch CL, et al. Among authors: naylor a. J Antibiot (Tokyo). 1998 Feb;51(2):210-20. doi: 10.7164/antibiotics.51.210. J Antibiot (Tokyo). 1998. PMID: 9544943 Free article.
825 results