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Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.
Vasireddy V, Uchida Y, Salem N Jr, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. Vasireddy V, et al. Among authors: dlugosz a. Hum Mol Genet. 2007 Mar 1;16(5):471-82. doi: 10.1093/hmg/ddl480. Epub 2007 Jan 5. Hum Mol Genet. 2007. PMID: 17208947 Free PMC article.
Basal cell carcinomas in mice overexpressing Gli2 in skin.
Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui CC, Dlugosz AA. Grachtchouk M, et al. Among authors: dlugosz aa. Nat Genet. 2000 Mar;24(3):216-7. doi: 10.1038/73417. Nat Genet. 2000. PMID: 10700170 No abstract available.
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL. Wang B, et al. Among authors: dlugosz aa. J Biol Chem. 2016 Feb 5;291(6):3030-42. doi: 10.1074/jbc.M115.676601. Epub 2015 Nov 24. J Biol Chem. 2016. PMID: 26601958 Free PMC article.
Lack of evidence for activation of the hedgehog pathway in psoriasis.
Gudjonsson JE, Aphale A, Grachtchouk M, Ding J, Nair RP, Wang T, Voorhees JJ, Dlugosz AA, Elder JT. Gudjonsson JE, et al. Among authors: dlugosz aa. J Invest Dermatol. 2009 Mar;129(3):635-40. doi: 10.1038/jid.2008.266. Epub 2008 Aug 28. J Invest Dermatol. 2009. PMID: 18754037 Free PMC article.
265 results