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Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.
Zhang Y, Cao R, Yin F, Lin FY, Wang H, Krysiak K, No JH, Mukkamala D, Houlihan K, Li J, Morita CT, Oldfield E. Zhang Y, et al. Among authors: oldfield e. Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1136-8. doi: 10.1002/anie.200905933. Angew Chem Int Ed Engl. 2010. PMID: 20039246 Free PMC article. No abstract available.
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
Sanders JM, Ghosh S, Chan JM, Meints G, Wang H, Raker AM, Song Y, Colantino A, Burzynska A, Kafarski P, Morita CT, Oldfield E. Sanders JM, et al. Among authors: oldfield e. J Med Chem. 2004 Jan 15;47(2):375-84. doi: 10.1021/jm0303709. J Med Chem. 2004. PMID: 14711309
The bisphosphonate gammadelta T cell activation pharmacophore differs considerably, however, from that reported previously for gammadelta T cell activation by phosphoantigens (Gossman, W.; Oldfield, E. J. Med. Chem. 2002, 45, 4868-4874), suggesting different primary …
The bisphosphonate gammadelta T cell activation pharmacophore differs considerably, however, from that reported previously for gammadelta T …
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, van Beek ER, Papapoulos SE, Morita CT, Oldfield E. Sanders JM, et al. Among authors: oldfield e. J Med Chem. 2005 Apr 21;48(8):2957-63. doi: 10.1021/jm040209d. J Med Chem. 2005. PMID: 15828834
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Hudock MP, Sanz-Rodríguez CE, Song Y, Chan JM, Zhang Y, Odeh S, Kosztowski T, Leon-Rossell A, Concepción JL, Yardley V, Croft SL, Urbina JA, Oldfield E. Hudock MP, et al. Among authors: oldfield e. J Med Chem. 2006 Jan 12;49(1):215-23. doi: 10.1021/jm0582625. J Med Chem. 2006. PMID: 16392806
928 results