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Page 1
Agonist lead identification for the high affinity niacin receptor GPR109a.
Gharbaoui T, Skinner PJ, Shin YJ, Averbuj C, Jung JK, Johnson BR, Duong T, Decaire M, Uy J, Cherrier MC, Webb PJ, Tamura SY, Zou N, Rodriguez N, Boatman PD, Sage CR, Lindstrom A, Xu J, Schrader TO, Smith BM, Chen R, Richman JG, Connolly DT, Colletti SL, Tata JR, Semple G. Gharbaoui T, et al. Among authors: connolly dt. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4914-9. doi: 10.1016/j.bmcl.2007.06.028. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17588745
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.
Skinner PJ, Cherrier MC, Webb PJ, Shin YJ, Gharbaoui T, Lindstrom A, Hong V, Tamura SY, Dang HT, Pride CC, Chen R, Richman JG, Connolly DT, Semple G. Skinner PJ, et al. Among authors: connolly dt. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5620-3. doi: 10.1016/j.bmcl.2007.07.101. Epub 2007 Aug 23. Bioorg Med Chem Lett. 2007. PMID: 17804224
The role of the GPR91 ligand succinate in hematopoiesis.
Hakak Y, Lehmann-Bruinsma K, Phillips S, Le T, Liaw C, Connolly DT, Behan DP. Hakak Y, et al. Among authors: connolly dt. J Leukoc Biol. 2009 May;85(5):837-43. doi: 10.1189/jlb.1008618. Epub 2009 Feb 9. J Leukoc Biol. 2009. PMID: 19204147
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
Boatman PD, Lauring B, Schrader TO, Kasem M, Johnson BR, Skinner P, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Luo WL, Caro L, Cote J, Lai E, Wagner J, Taggart AK, Carballo-Jane E, Hammond M, Colletti SL, Tata JR, Connolly DT, Waters MG, Richman JG. Boatman PD, et al. Among authors: connolly dt. J Med Chem. 2012 Apr 26;55(8):3644-66. doi: 10.1021/jm2010964. Epub 2012 Apr 9. J Med Chem. 2012. PMID: 22435740 Clinical Trial.
Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist.
Adams JW, Ramirez J, Ortuno D, Shi Y, Thomsen W, Richman JG, Morgan M, Dosa P, Teegarden BR, Al-Shamma H, Behan DP, Connolly DT. Adams JW, et al. Among authors: connolly dt. Eur J Pharmacol. 2008 May 31;586(1-3):234-43. doi: 10.1016/j.ejphar.2007.11.056. Epub 2007 Dec 3. Eur J Pharmacol. 2008. PMID: 18358471
57 results