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Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE. Zakharova VM, et al. Among authors: serpi m. J Med Chem. 2011 Aug 25;54(16):5680-93. doi: 10.1021/jm2001426. Epub 2011 Aug 3. J Med Chem. 2011. PMID: 21812420 Free PMC article.
Synthesis of phosphoramidate prodrugs: ProTide approach.
Serpi M, Madela K, Pertusati F, Slusarczyk M. Serpi M, et al. Curr Protoc Nucleic Acid Chem. 2013 Jun;Chapter 15:15.5.1-15.5.15. doi: 10.1002/0471142700.nc1505s53. Curr Protoc Nucleic Acid Chem. 2013. PMID: 23775807
42 results