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Locked nucleic acid: tighter is different.
Watts JK. Watts JK. Chem Commun (Camb). 2013 Jun 25;49(50):5618-20. doi: 10.1039/c3cc40340h. Epub 2013 May 16. Chem Commun (Camb). 2013. PMID: 23682352 Free article.
Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.
Pendergraff HM, Krishnamurthy PM, Debacker AJ, Moazami MP, Sharma VK, Niitsoo L, Yu Y, Tan YN, Haitchi HM, Watts JK. Pendergraff HM, et al. Among authors: watts jk. Mol Ther Nucleic Acids. 2017 Sep 15;8:158-168. doi: 10.1016/j.omtn.2017.06.012. Epub 2017 Jun 21. Mol Ther Nucleic Acids. 2017. PMID: 28918018 Free PMC article.
Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.
Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Osborn MF, et al. Among authors: watts jk. Mol Cancer Ther. 2018 Jun;17(6):1251-1258. doi: 10.1158/1535-7163.MCT-17-1144. Epub 2018 Apr 13. Mol Cancer Ther. 2018. PMID: 29654062 Free PMC article.
66 results